Optimizing miRNA-module diagnostic biomarkers of gastric carcinoma via integrated network analysis.
Several microRNAs (miRNAs) have been suggested as novel biomarkers for diagnosing gastric cancer (GC) at an early stage, but the single-marker strategy may ignore the co-regulatory relationships and lead to low diagnostic specificity.Thus, multi-target modular diagnostic biomarkers are urgently needed.In this study, a Zsummary and NetSVM-based meth